منابع مشابه
Pathogenesis of Scleroderma
The term "scleroderma" traditionally has been uti l ized to describe the cutaneous changes of a heterogeneous group of disorders involving hardening, tightening, and decreased elasticity of the skin.' Two extreme forms have been identified-localized and diffuse. The localized form, specifically morphea, i s characterized by well-circumscribed, sclerotic plaques with an ivory-colored center and ...
متن کاملPathogenesis of scleroderma (systemic sclerosis).
Increasing interest in the vascular features of scleroderma has led to the hypothesis that the blood vessel is the major target tissue and that the endothelial cell is the principal cell target. Useful observations stemming from the vascular hypothesis include the use of microvascular abnormalities in the early detection of the patient destined to develop classical scleroderma, the discovery of...
متن کاملA brief overview of the pathogenesis of scleroderma (systemic sclerosis).
Although definitive answers are not yet forthcoming, understanding the mechanisms of fibrosis in scleroderma might improve the relative therapeutic vacuum now surrounding not only generalised scleroderma (systemic sclerosis (SSc)) but also the fibrosis of keloid formation, cirrhosis of the liver, pulmonary fibrosis, and atherosclerosis as well. Discussion here will include immune, vascular, and...
متن کاملThe pathogenesis of esophageal dysfunction in scleroderma and Raynaud's disease.
To determine the pathogenesis of esophageal dysfunction in scleroderma and Raynaud's disease, the lower esophageal sphincter (LES) was tested with: (a) methacholine acting directly at the cholinergic receptor on the muscle; (b) edrophonium, a cholinesterase inhibitor, enhancing the effect of released acetylcholine; and (c) gastrin I, acting through the release of acetylcholine. 10 patients with...
متن کاملScleroderma pathogenesis: a pivotal role for fibroblasts as effector cells
Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury. Fibroblasts are the resident cells of connective tissue that become activate...
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ژورنال
عنوان ژورنال: International Journal of Dermatology
سال: 1984
ISSN: 0011-9059,1365-4632
DOI: 10.1111/j.1365-4362.1984.tb05678.x